New PDF release: The Picornaviruses

By Ellie Ehrenfeld, Esteban Domingo, Raymond P. Roos

ISBN-10: 1555816037

ISBN-13: 9781555816032

A springboard for constructing new techniques to realizing, combating, and treating picornaviral ailments.

  • Examines the most up-tp-date breakthroughs in addition to the demanding situations that lie forward in picornavirus study; encapsulates present wisdom of the molecular biology, evolution, and pathogenesis of this huge relations of viruses; and, examines the illnesses that those viruses reason and the newest vaccines and antiviral medicines to avoid and keep an eye on these illnesses.
  • Explores the structural and mechanistic bases of picornavirus replication, highlighting new insights in regards to the host mobilephone interactions wanted for virus development; and, illustrates how the ordinary incidence of mutations, commonplace of viruses with RNA as genetic fabric, generates the quasispecies dynamics that underlie viral health.
  • Focuses on picornaviruses that reason ailment, interpreting pathogenicity and innate and purchased immune responses opposed to an infection in addition to the newest vaccine and antiviral drug suggestions.

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Additional resources for The Picornaviruses

Sample text

2003. Genomic evidence that simian virus 2 and six other simian picornaviruses represent a new genus in Picornaviridae. Virology 314: 283–293. 63. Oh, H. , H. B. Pathak, I. G. Goodfellow, J. J.  E. Cameron. 2009. Insight into poliovirus genome replication and encapsidation obtained from studies of 3B-3C cleavage site mutants. J. Virol. 83:9370–9387. 64. Pacheco, J. , T. M. Henry, V. K. O’Donnell, J. B. Gregory, and P. W. Mason. 2003. Role of nonstructural proteins 3A and 3B in host range and pathogenicity of foot-and- mouth disease virus.

J. Virol. 50:957–959. 80. , C. Krogerus, T. Poyry, and T. Hyypia. 2004. Specific interaction between human parechovirus nonstructural 2A protein and viral RNA. J. Biol. Chem. 279:37822– 37831. 81. Schein, C. , N. Oezguen, D. E. Volk, R. Garimella, A. Paul, and W. Braun. 2006. NMR structure of the viral peptide linked to the genome (VPg) of poliovirus. Peptides 27:1676–1684. 82. , A. Guarne, E. Bergmann, M. James, W. Sommergruber, I. Fita, and T. Skern. 1999. The structures of picornaviral proteinases.

P. Ficorilli, and M. J. Studdert. 2005. Sequence variation divides Equine rhinitis B virus into three distinct phylogenetic groups that correlate with serotype and acid stability. J. Gen. Virol. 86:2323–2332. Black, W. , and M. J. Studdert. 2006. Formerly unclassified, acid-stable equine picornaviruses are a third equine rhinitis B virus serotype in the genus Erbovirus. J. Gen. Virol. 87:3023– 3027. , A. Kapoor, J. Victoria, M. Jones, N. Wolfe, A. Naeem, S. Shaukat, S. Sharif, M. M. Alam, M. Angez, S.

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The Picornaviruses by Ellie Ehrenfeld, Esteban Domingo, Raymond P. Roos


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