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Extra resources for Quasispecies and RNA Virus Evolution: Principles and Consequences (Molecular Biology Intelligence Unit)

Example text

Holland JJ, Spindler K, Horodyski F et al. Rapid evolution of RNA genomes. Science 1982; 215: 1577-85. 31. Hu J, Seeger C. RNA signals that control DNA replication in hepadnaviruses. Seminars in Virology 1997; 8:205-11. 32. Ionov Y, Peinado MA, Malkhosyan S et al. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 1993; 36:558-61. 33. Kamen RI. Structure and function of the Qβ RNA replicase. In: Zinder ND, ed. RNA phages. Cold Spring Harbor Laboratory 1975:203-34.

31. Hu J, Seeger C. RNA signals that control DNA replication in hepadnaviruses. Seminars in Virology 1997; 8:205-11. 32. Ionov Y, Peinado MA, Malkhosyan S et al. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 1993; 36:558-61. 33. Kamen RI. Structure and function of the Qβ RNA replicase. In: Zinder ND, ed. RNA phages. Cold Spring Harbor Laboratory 1975:203-34. 34. Kunkel LO. Publ Am Assoc Adv Sci 1940; 12:22. 35. Kurath G, Robaglia C.

Molecular Recognition and Replication Enzymes 39 A well known example of a viral polymerase composed of virus-coded as well as host proteins is the Qβ replicase, which can be purified from bacteriophage Qβ-infected Escherichia coli cells. This enzyme provided the basis for the first in vitro RNA replication system capable of catalyzing the test tube synthesis of infectious viral RNA from nucleotide substrates under the required ionic conditions. This work was initiated by Sol Spiegelman and associates, and then followed by the groups of C.

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