By W. G. Wood, C. Gorka, A. M. Rao, F. Schroeder (auth.), Grace Y. Sun, P. Kevin Rudeen, W. Gibson Wood, Yau-Huei Wei, Albert Y. Sun (eds.)
ISBN-10: 1461245141
ISBN-13: 9781461245148
ISBN-10: 146128855X
ISBN-13: 9781461288558
Alcohol abuse during the global is linked to severe social and scientific implications. difficulties akin to intoxication, tol erance, and improvement of actual dependence were good famous. The critical fearful method and the liver are particularly affected. there's little question that alcohol abuse can lead to organ harm, which in flip ends up in deleterious healthiness outcomes to the person. figuring out ethanol motion offers a different and sensible diver problem as a result of its molecular simplicity sity. actually, the facility for alcohol to disrupt mobile functionality is at tributed to its mobile harm with no regard to an obvious particular mechanism of motion. however, the main to an efficient remedy to this challenge is thru examine into realizing the mechan isms underlying how ethanol interacts with cells and membranes. This ebook is the results of a cooperative attempt between scientists from many countries who met in a symposium in Taipei, Taiwan, ROC, July 1988. the focal point of this booklet is on experimental ap proaches to raised comprehend the molecular mechanisms of ethanol at the organic method. those contemporary advances within the exam of the alcohol results on mobile functionality are divided into 4 sec tions. the 1st part addresses particular activities of ethanol at the primary worried approach. the second one part is directed to using mobilephone cuI tures in ethanol learn and the usefulness of cellphone cultures in exam of the results of ethanol in vitro.
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Additional resources for Molecular Mechanisms of Alcohol: Neurobiology and Metabolism
Example text
Pharma. Exp. Therapeutics 237, 92-98 21. , Eichberg, J. and Hauser, G. (1971) Biochim. Biophys. Acta 248, 96-104. 22. D. Dissertation, Univ. Lund, Sweden. 23. HarriS, RA and Schroeder, F. (1981) Mol. Pharmacol. 20, 128-137. 24. A and Hitzemann, RJ. (1981) Science 212, 1290-1291. 25. A and Hitzemann, RJ. (1984) Mol. Pharmacol. 25, 401-409. 26. P. (1986) Biochim. et Biophys. Acta 859, 189197 27. , Moses, F. R and Tabakoff, B. (1986) Mol. Pharmacol. 30, 13-18. 28. Y. (1986) Neurochem. In!. 9, 185190.
Results of oreliminary studies have indicated that a longer time than that for 32pi is needed for labeling the phosphoinositides with 3H-inositol. This labeled precursor can be effectively incorporated into phosphoinositides as well as inositol phosphates. Although a large portion of the label is incorporated into PI, very little label is found in poly-PI (Fig 4). Analysis of the water soluble inositol 31 Brain Acidic Phospholipids 500 5000 450 ..... ,:E 350 :E 1 hr iZl "hr ~ 16hr 300 3000 CI. o 250 200 2000 ...
Two alpha r receptor subtypes are proposed which couple to PI hydrolysis by the subsequent increase in intracellular calcium activates poly-PI hydrolysis by a direct stimulation of phospholipase C. Ethanol different mechanisms. The alpha 1b subtype directly stimulates poly-PI hydrolysis via a receptor-G-protein phospholipase C interaction. The alpha1a subtype stimulates calcium influx, and does not interfere with receptor-G-protein-phospholipase C coupling and, therefore, has no effect on alpha 1b stimulated polyPI hydrolysis.
Molecular Mechanisms of Alcohol: Neurobiology and Metabolism by W. G. Wood, C. Gorka, A. M. Rao, F. Schroeder (auth.), Grace Y. Sun, P. Kevin Rudeen, W. Gibson Wood, Yau-Huei Wei, Albert Y. Sun (eds.)
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