By Derek J Sullivan, Gary P Moran
ISBN-10: 1908230444
ISBN-13: 9781908230447
Fungi reason a spectrum of ailments in people, starting from relatively harmless superficial epidermis illnesses because of dermatophytes to invasive life-threatening infections attributable to species comparable to Candida albicans, or Cryptococcus neoformans. a result of opportunistic nature of such a lot invasive mycoses, fungal pathogenicity has confirmed tricky to outline. even though, the applying of latest genomic and different molecular ideas in recent times has revolutionized the sphere, revealing interesting new insights into the mechanisms of fungal pathogenesis. during this e-book, a panel of excessive profile participants severely assessment crucial learn to supply a well timed evaluation. The ebook is split into sections. the 1st six chapters evaluate the transformative impression of utilising state of the art instruments and leading edge ways to analyze, rather within the region of comparative biology. the second one part involves 8 chapters, every one devoted to the molecular and mobile biology of an immense fungal pathogen of people: Candida, Aspergillus, Cryptococcus, Dermatophytes, Histoplasma, Blastomyces, Pneumocystis, and Paracoccidoides. those chapters offer a well timed picture of the present kingdom of study. The publication might be a necessary reference for college kids, researchers, and clinicians with an curiosity in fungal pathogenesis. [Subject: Molecular Biology, Epidemiology, existence technology]
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Extra resources for Human Pathogenic Fungi: Molecular Biology and Pathogenic Mechanisms
Sample text
6 7229 Sharpton et al. (2009) U. 2 7798 Sharpton et al. (2009) H. 8 9390 Sharpton et al. (2009) P. 4 3898 Cisse et al. (2013) P. 5 4591 Hauser et al. (2010) T. 3 8707 Martinez et al. (2012) T. 1 8523 Martinez et al. (2012) T. 3 8679 Martinez et al. (2012) M. 5 8915 Martinez et al. (2012) M. 5 8907 Martinez et al. (2012) T. 2 8024 Burmester et al. (2011) A. 7 7980 Burmester et al. (2011) R. 6 17,467 Ma et al. (2009) In an attempt to uncover the genetic mechanisms that may have led to these alternative phenotypes strain specific genes were investigated.
The lack of a long-term in vitro culture method for P. , 2010). To help uncover some of the possible molecular mechanisms utilized by P. , 2010). P. carinii infects rats and is closely related to P. jirovecii. Using S. pombe as a control, ~4000 putative P. 2). By mapping the proteome of P. carinii and S. , 1999), the authors observed that genes involved in amino acid metabolism were significantly underrepresented in P. , 2010). Furthermore only 2 of the 54 genes specifically dedicated to the metabolism of the 20 standard amino acids are present in P.
2010). The complete sequence of the smallest known nuclear genome from the microsporidian Encephalitozoon intestinalis. Nat. Commun. 1, 77. , and Sanglard, D. (2004). TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2. Eukaryot. Cell 3, 1639–1652. M. (2000). Evolution of drug resistance in experimental populations of Candida albicans. J. Bacteriol. 182, 1515–1522. R. (2010). Stealth and opportunism: alternative lifestyles of species in the fungal genus Pneumocystis.
Human Pathogenic Fungi: Molecular Biology and Pathogenic Mechanisms by Derek J Sullivan, Gary P Moran
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